Science Advances
February 5, 2020
Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair
Zhenhua Li1,2,*, Shiqi Hu1,2,*, Ke Huang1, Teng Su1,2, Jhon Cores1,2 and Ke Cheng1,2,
1 Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
2 Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.
† Corresponding author.
* These authors contributed equally to this work.
10.1126/sciadv.aay0589
To explore a novel approach that could both deliver therapeutic cells to the tissue and make the tissue more receptive upon their arrival, Li et al. fabricated platelet microparticles and equipped them with anti-interleukin (IL)-1β antibodies designed to block Interleukin (IL)-1β, which plays a central role in the inflammatory response triggered by a heart attack that causes further injury and makes it difficult for the tissue to heal. They found that the platelet microparticles could successfully bind to injured animal heart tissue, protecting heart muscle cells from cell death and inducing cardiac tissue repair.
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