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Nature Metabolism Journal Cover Design Service (Omics for hypoxia-targeted therapy)

  • Nature Metabolism

  • 18 March 2019

  • Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

  • Youqiong Ye1,15, Qingsong Hu2,15, Hu Chen3,4, Ke Liang2, Yuan Yuan3, Yu Xiang1, Hang Ruan1, Zhao Zhang1, Anren Song1, Huiwen Zhang1, Lingxiang Liu5, Lixia Diao3, Yanyan Lou6, Bingying Zhou7, Li Wang7, Shengtao Zhou8, Jianjun Gao9, Eric Jonasch9, Steven H. Lin10, Yang Xia1,11, Chunru Lin2,11, Liuqing Yang2,11*, Gordon B. Mills12,13, Han Liang3,4,11,12, and Leng Han1,11,14*

  • 1 Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.

    2 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    3 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    4 Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX, USA.

    5 Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    6 Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.

    7 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

    8 Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China.

    9 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    10 Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    11 MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.

    12 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

    13 Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.

    14 Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

    15 These authors contributed equally: Youqiong Ye, Qingsong Hu.

  • 10.1038/s42255-019-0045-8

  • This study characterizes multi-omic signatures that are associated with the hypoxia status of cancer cells and correlate with drug resistance or drug sensitivity, thus contrasting the conventional view that hypoxia confers drug resistance. Ninety-one percent of clinically actionable genes may be affected by hypoxia status.

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