Molecular Cell Journal Cover Design Service (p300 Turns PKM2 into a Protein Kinase)

Molecular Cell

November 7, 2013

Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM₂ Protein Kinase Activity and Nuclear Localization

Lei Lv^1,2,3,7,8 ,Yan-Ping Xu^1,2,3,7 ,Di Zhao^1,2 , Fu-Long Li^1,2,3 ,Wei Wang⁵ , Naoya Sasaki⁶ ,Ying Jiang⁴ , Xin Zhou^1,2,3 ,Ting-Ting Li^1,2,3 ,Kun-Liang Guan⁵ , Qun-Ying Lei^1,2 , Yue Xiong^3,6,*

10.1039/D4CC04301D

Magicians like to use the hat as a prop to do magic tricks, like transforming one animal to another. The image illustrates a model that acetylation by p300 histone acetyltransferase (HAT) converts PKM2 from a cytoplasmic metabolite kinase to a nuclear protein kinase, as described by Lv et al. in this issue (pp. 340–352). A bird (pyruvate kinase) eating a small worm (phosphoenolpyruvate, PEP) is transformed by the magic hat (p300 HAT) to a rabbit (protein kinase) eating a large carrot (protein substrates). Image concept by Yue Xiong;