Nature Chemical Biology
20 February 2017
Expanding the product portfolio of fungal type I fatty acid synthases
Zhiwei Zhu1–3, Yongjin J Zhou1,3, Anastasia Krivoruchko1,3,4, Martin Grininger5, Zongbao K Zhao2,6* & Jens Nielsen1,3,4,7,8*
1 Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
2 Division of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian, China.
3 Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden.
4 Biopetrolia AB, Systems and Synthetic Biology, Chalmers University of Technology, Gothenburg, Sweden.
5 Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence for Macromolecular Complexes, Goethe University Frankfurt, Frankfurt am Main, Germany.
6 Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, CAS, Dalian, China.
7 Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark.
8 Science for Life Laboratory, Royal Institute of Technology, Stockholm, Sweden.
10.1038/nchembio.2301
Fatty acid synthase (FAS) is a multidomain enzyme complex that can be engineered to generate non-native fatty acids and ketones. The cover depicts the structure of yeast FAS in cross-section, with a miniature factory inside its reaction chamber to represent the production and export of these molecules.
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