Circulation Research
4 December 2023
CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6
Yuhu He1, Pu Zou1, Junmi Lu2, Yufei Lu3, Shuguang Yuan4, Xialei Zheng1, Jing Liu1, Cheng Zeng1, Ling Liu1, Liang Tang1, Zhenfei Fang1, Xinqun Hu1, Qiming Liu1, Shenghua Zhou1
1 Departments of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
2 Departments of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
3 Division of Physical Therapy Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha
4 Departments of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
† Y. He and P. Zou contributed equally.
10.1161/CIRCRESAHA.123.322835
LGMN deficiency in T cells prevents hypertension and its complications by promoting Treg differentiation and function. Specifically targeting LGMN in Tregs may be an innovative approach for hypertension treatment.
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