Nature Cell Biology
10 June 2024
Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma.
Lele Wu1,10, Zheng Zhao2,10, Yong Jae Shin3,10, Yiyun Yin2,10, Anandhkumar Raju1, Thamil Selvan Vaiyapuri1, Khaireen Idzham1, Miseol Son3, Yeri Lee3, Jason K. Sa4, Joelle Yi Heng Chua1, Bilal Unal1, You Zhai2, Wenhua Fan2,5, Lijie Huang2, Huimin Hu2, Jayantha Gunaratne6, Do-Hyun Nam3,7, Tao Jiang2,5,11✉ & Vinay Tergaonkar1,8,9,11✉
1 Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Republic of Singapore.
2 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
3 Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.
4 Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
5 Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
6 Laboratory of Translational Biomedical Proteomics, Institute of Molecular and Cell Biology (IMCB), Agency for Science Technology and Research (A*STAR), Singapore, Republic of Singapore.
7 Department of Neurosurgery, Samsung Medical Center, Seoul, Republic of Korea.
8 Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Republic of Singapore.
9 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Republic of Singapore.
10 These authors contributed equally: Lele Wu, Zheng Zhao, Yong Jae Shin, Yiyun Yin.
11 These authors jointly supervised this work: Tao Jiang, Vinay Tergaonkar.
10.1038/s41556-024-01428-5
The authors show that the RNA–RNA-binding protein complex LOC–DHX15 drives microglia infiltration into the tumour microenvironment in glioblastoma.
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