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Journal Cover Design Service (Temporal Profiling of the Secretome)

Nature Methods Journal Cover Design Service (Temporal Profiling of the Secretome)

  • Nature Methods

  • 10 April 2023

  • Time-resolved assessment of single-cell protein secretion by sequencing

  • Tongjin Wu1,2, Howard John Womersley2, Jiehao Ray Wang3, Jonathan Scolnick3,4 & Lih Feng Cheow1,2

  • 1 Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore, Singapore.

    2 Institute for Health Innovation and Technology, National University of Singapore, Singapore, Singapore.

    3 Singleron Biotechnologies Pte. Ltd., Singapore, Singapore.

    4 Healthy Longevity Translational Research Program, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

  • 10.1038/s41592-023-01841-y

  • Capture of secreted proteins onto their source cell surfaces using an affinity matrix enables simultaneous measurement of protein secretion, cell surface proteins and transcriptomes in thousands of cells at single-cell resolution.

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