Analytical Chemistry
1 August 2023
Identification and Characterization of DNA–Oxaliplatin Adducts through α-hemolysin Nanopores
Ting Li*a, Wei Luc, Hui Tiana, Yu Caoa,c, Qianqian Hea, Xia Chena,b, Hailong Wangb
a College of Life Science & Biotechnology, Mianyang Normal University, Mianyang 621000, China
b China Academy of Engineering Physics, Institute of Nuclear Physics and Chemistry, Mianyang 621000, China
c Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
10.1021/acs.analchem.3c00461
Interesting nanopore signals of type I (blue mark) and type II (pink mark) with specific features generated when DNA-Oxaliplatin interacted with α-hemolysin nanopore, a mushroom-like heptamer protein, which comprises 293 amino acids. The signals were certified to be produced by DNA-Oxaliplatin di-adducts.
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