Nano Research
25 July 2023
Size-transformable nanoparticles with sequentially triggered drug release and enhanced penetration for anticancer therapy
Yulin Li1,5✉, Liudi Wang1, Guoqiang Zhong1, Guoying Wang1, Yanzhao Zhu4, Jian Li2, Lan Xiao6, Yanhui Chu4, Yan Wu4✉, Kaichun Li2✉, Jie Gao3✉
1 Engineering Research Centre for Biomedical Materials of Ministry of Education, The Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
2 Department of Oncology Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China
3 Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China
4 College of Life Sciences Mudanjiang Medical University, Mudanjiang 157011, China
5 Wenzhou Institute of Shanghai University, Wenzhou 325000, China
6 Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD 4059, Australia
§ Yulin Li, Liudi Wang, Guoqiang Zhong, Guoying Wang, and Yanzhao Zhu contributed equally to this work.
10.1007/s12274-023-5833-5
There are several limitations to the application of nanoparticles in the treatment of cancer, including their low drug loading, poor colloidal stability, insufficient tumor penetration, and uncontrolled release of the drug. Herein, gelatin/laponite (LP)/doxorubicin (GLD) nanoparticles are developed by crosslinking LP with gelatin for doxorubicin delivery. GLD shows high doxorubicin encapsulation efficacy (99%) and strong colloidal stability, as seen from the unchanged size over the past 21 days and reduced protein absorption by 48-fold compared with unmodified laponite/doxorubicin nanoparticles.
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