Advanced Functional Materials
20 January 2023
Nanobiology Dependent Therapeutic Convergence between Biocompatibility and Bioeffectiveness of Graphene Oxide Quantum Dot Scaffold for Immuno-Inductive Angiogenesis and Nerve Regeneration
Zhiwen Yan1,2,3,†, Tianbao Ye4,†, Liang Yang1,2,3,†, Huiquan Jiang1,2,3, Cheng Chen5, Shanlin Chen6,*, Yun Qian1,2,3,* and Cunyi Fan1,2,3,*
1 Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233 P. R. China
2 Shanghai Engineering Research Center for Orthopedic Material Innovation and Tissue Regeneration, Shanghai, 200233 P. R. China
3 Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine, Shanghai, 200233 P. R. China
4 Department of Cardiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233 P. R. China
5 Department of Orthopedics, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065 P. R. China
6 Department of Hand Surgery, Beijing Ji Shui Tan Hospital, Beijing, 102208 P. R. China
† Z.Y., T.Y., and L.Y. contributed equally to this work.
10.1002/adfm.202211709
Owing to the ability to tune neuronal behavior, graphene and its derivatives hold huge promise in engineering advanced functional nanomaterials for peripheral nerve repair. In article number 2211709, Shanlin Chen, Yun Qian, Cunyi Fan, and co-workers demonstrate that the graphene oxide quantum dot is a biocompatible and bioeffective agent to facilitate intraneural vascularization via macrophage ERK/CREB/VEGF signaling axis during peripheral nerve regeneration.
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