Virologica Sinica Journal Cover Design Service (HAdVs)

Virologica Sinica

26 May 2020

Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: "Adenovirus Vaccine Within an Adenovirus Vector"

Yuqian Yan ¹, Shuping Jing ^1,2 , Liqiang Feng ³ , Jing Zhang ⁴ , Zhiwei Zeng ¹ , Min Li ¹ , Shan Zhao ¹ , Junxian Ou ¹ , Wendong Lan ¹ , Wenyi Guan ¹ , Xiaowei Wu ¹ , Jianguo Wu ⁴ , Donald Seto ⁵ , Qiwei Zhang ^1,4 

10.1007/s12250-020-00234-1

Human adenoviruses (HAdVs) are non-enveloped double-stranded DNA viruses which belong to the genus Mastadenovirus. To date, over 100 genotypes of HAdVs have been recognized and are classified into seven species (A–G). HAdVs are highly contagious that could cause multiple systemic infections, such as acute respiratory disease, epidemic keratoconjunctivitis, hemorrhagic cystitis, gastroenteritis, as well as other diseases. HAdVs-associated respiratory tract infection is one of the leading causes of severe respiratory tract diseases in pediatric populations, characterized by poor prognosis, high mortality, severe complications, and serious sequelae. However, there is no recommended effective drug for adenovirus infections. To further advance our knowledge on HAdVs, we dedicate a special topic covering the latest researches on clinical diagnosis, epidemiology, detection methods, vaccine development, and HAdV-associated severe diseases. The cover is modified from an electron micrograph of the rAd3H recombinant vaccine virus (kindly provided by Prof. Qiwei Zhang) with artistic processing.