Advanced Healthcare Materials
19 May 2023
In Vivo Stable Allogenic Cartilage Regeneration in a Goat Model Based on Immunoisolation Strategy Using Electrospun Semipermeable Membranes
Yingying Huo1,2,†, Baoshuai Bai3,†, Rui Zheng1,2,†, Yuyan Sun3, Yao Yu3, Xin Wang4,5, Hong Chen5, Yujie Hua1,2,6,*, Yixin Zhang1,2,*, Guangdong Zhou1,2,3,6,* and Xiaoyun Wang4,5,*
1 Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, 200011 PR China
2 National Tissue Engineering Center of China, Shanghai, 200241 PR China
3 Research Institute of Plastic Surgery, Weifang Medical University, Weifang, Shandong, 261053 PR China
4 Department of Plastic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, 200050 PR China
5 Department of Hand Surgery, Ningbo Sixth Hospital, Ningbo, Zhejiang, 315042 PR China
6 Institute of Regenerative Medicine and Orthopedics, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, Henan, 453003 PR China
† Y.H., B.B., and R.Z. contributed equally to this work.
10.1002/adhm.202203084
A novel immunoisolation strategy based on a hybrid synthetic–natural electrospun semipermeable membrane is reported in article 2203084 by Yujie Hua, Yixin Zhang, Guangdong Zhou, Xiaoyun Wang, and co-workers. The immunoisolation mechanism is dependent on preventing immune cell attack by the physical barrier and blocking the negative regulatory effect mediated by destructive inflammatory factors, and thus successfully achieving stable allogenic cartilage regeneration in a goat model.
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