Neuroscience Bulletin
16 July 2024
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model
Chenrui Yin1†, Kefei Luo1†, Xinyue Zhu1†, Ronghang Zheng1†, Yu Wang2, Guangdan Yu3, Xiaorui Wang1, Fei She4, Xiaoying Chen1, Tao Li1, Jingfei Chen1, Baduojie Bian5, Yixun Su6✉, Jianqin Niu1✉, Yuxin Wang1,5✉
1 Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, China
2 Department of Respiratory Diseases, Central Medical Branch of PLA General Hospital, Beijing 100853, China
3 China Astronaut Research and Training Center, Beijing 100094, China
4 Department of Emergency, the Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100142, China
5 Army 953 Hospital, Shigatse Branch of Xinqiao Hospital, Third Military Medical University (Army Medical University), Shigatse 857000, China
6 Research Centre, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China,Chenrui Yin, Kefei Luo, Xinyue Zhu, and Ronghang Zheng contributed equally to this work.
10.1007/s12264-024-01249-4
Recent studies reported that newly formed myelin could shape neural circuit function and be implicated in fear memory preservation. However, its role in PTSD remains to be elucidated. In this study, we adopted a restraint stress-induced PTSD mouse model and found that PTSD-related neuropsychiatric symptoms were accompanied by increased myelination in the posterior parietal cortex and hippocampus.
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