Advanced Materials
30 September 2024
Piezoelectric-Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis
Min Ge1, Wanbo Zhu2, Jiawei Mei3, Tingting Hu1, Chuang Yang2,*, Han Lin4,5,* and Jianlin Shi4,5,*
1 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, 999077 China
2 Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233 China
3 Department of Orthopaedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001 China
4 Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai, 200050 China
5 Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200331 China
† M.G. and W.Z. contributed equally to this work.
10.1002/adma.202409633
In article number 2409633, Min Ge, Chuang Yang, Han Lin, Jianlin Shi, and co-workers developed a physical and chemical barrier breakthrough strategy for biofilms via redox homeostasis manipulation. The nanosystem can enhance the attack of ROS via exogenous stimulation while providing interference with endogenous H2S synthase to reduce the resistance of reducing species, which together lead to severe structural damage in biofilms. In addition, oxidative stress mediates N1 polarization of neutrophils, leading to immunobactericidal effects.
Anhui Province Academy of Science and Technology, No. 128,Wanshui Road, Hi-Tech Zone, Hefei City, Anhui Province, China
+86 17354022649
service@sondii.com
IPv6 network supported
Our hours
Beijing time: 9:00-18:00
