Advanced Science
04 February 2025
Resensitizing β-Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment
Tingwang Shi1,†, Qiong Wu2,†, Zesong Ruan1,†, Zhiyuan Luo1, Wenbo Wang1, Zhao Guo1, Yihong Ma1, Xin Wang1, Guangyu Chu3,4, Han Lin5, Min Ge6,* and Yunfeng Chen1,*
1 Department of Orthopedic Surgery, Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233 China
2 Department of Laboratory Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233 China
3 Department of Orthopedic Surgery, Spine Lab, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003 China
4 Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215 USA
5 Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences, Shanghai, 200050 China
6 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, 999077 China
† T.S., Q.W., and Z.R. contributed equally to thismanuscript.
10.1002/advs.202570025
The phenotypic instability of small colony variants (SCVs) complicates investigating their role in osteomyelitis. Min Ge, Yunfeng Chen, and co-workers clarified the pathogenic mechanism of clinically isolated SCVs with hpt mutations and proposed a nanomedicine system for co-delivering antibiotics to treat SCV-associated osteomyelitis.
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