Advanced Healthcare Materials
17 February 2023
Succinic Ester-Based Shape Memory Gelatin Sponge for Noncompressible Hemorrhage without Hindering Tissue Regeneration
Ye Zhu1,2, Lining Zhang3, Wanglin Duan1, Sergio Martin-Saldaña4, Chaowei Li1, Hongwen Yu1, Luyao Feng1, Xianpeng Zhang1, Baoji Du1, Guanying Li1, Xifu Zheng2 and Yazhong Bu1
1 Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061 P. R. China
2 Department of Orthopedic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011 P. R. China
3 Department of Rehabilitation Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853 P. R. China
4 POLYMAT, Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia-San Sebastián, 20018 Spain
† Y.Z. and L.Z. contributed equally to this work.
10.1002/adhm.202202122
In article 2202122, Xifu Zheng, Yazhong Bu, and co-workers successfully develop a fast degradable shape memory sponge for noncompressible hemorrhage without hindering tissue regeneration. The resulting sponge possesses high mechanical stability and hemostatic efficiency. Meanwhile, its fast degradation, resulting from succinic esters, leads to fast tissue regeneration when compared with a commercialized sponge. This sponge is composed of components with well-identified biocompatibility, making it very promising in the clinic.
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