Nano Letters
13 March 2023
Inorganic Nanosheet-Shielded Probiotics: A Self-Adaptable Oral Delivery System for Intestinal Disease Treatment
Ya-Xuan Zhu1,#, Yanling You2,3,#, Zhixin Chen2,3, Deliang Xu2,3, Wenwen Yue1, Xinxin Ma4, Junjie Jiang5, Wencheng Wu2, Han Lin1,2,*, and Jianlin Shi1,2,3,*
1 Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, P. R. China
2 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai 200050, P. R. China
3 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China
4 Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, P. R. China
5 Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China
# Y.-X.Z. and Y.Y. contributed equally to this manuscript.
10.1021/acs.nanolett.3c00118
This work presents a novel strategy for optimizing probiotic therapy against intestinal bowel diseases. SiH nanosheets coated on the surface of probiotics help to resist an erosive environment in the acidic stomach and can be degraded in the intestine to generate hydrogen as well as expose the probiotic bacteria for colitis amelioration.
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