Matter
2 February 2022
Freeform cell-laden cryobioprinting for shelf-ready tissue fabrication and storage
Hossein Ravanbakhsh1,2,8, Zeyu Luo1,3,8, Xiang Zhang1,4,5,8, Sushila Maharjan1, Hengameh S. Mirkarimi6, Guosheng Tang1, Carolina Chávez-Madero1,7, Luc Mongeau2, Yu Shrike Zhang1,9✉
1 Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA
2 Department of Mechanical Engineering, McGill University, Montreal, QC H3A0C3, Canada
3 Department of Orthopedics, West China Hospital/West China School of Medicine, Sichuan University, Chengdu 610041, P.R. China
4 School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou 450001, P. R. China
5 National Center for International Joint Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 450001, P. R. China
6 Department of Mechanical Engineering, École de technologie supérieure, Montreal, QC H3C1K3, Canada
7 Departamento de Ingeniería Mecatrónica y Electrónica, Escuela de Ingeniería y Ciencias, Tecnologico de Monterrey, Monterrey 64849, NL, México
8 These authors contributed equally
9 Lead contact
10.1016/j.matt.2021.11.020
As reported by Y.S. Zhang and colleagues in this issue of Matter, a cryobioprinting method is optimized for fabricating freeform storable tissue constructs with shelf availability by taking advantage of the designed cryoprotective bioinks to maintain the functionality of embedded cells during the cryobioprinting and cryostorage processes.
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