Cell metabolism
02 February 2021
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis
Yutian Chen1,6 ,Qiang Pu2,6 ,Yongyuan Ma1,6 ,Hua Zhang1,6 ,Tinghong Ye1,6 ,Chengjian Zhao1,6 ,Xiaojuan Huang1 ,Yafeng Ren1 ,Lina Qiao1 ,Han-Min Liu1 ,Charles T. Esmon3 ,Bi-Sen Ding1,4,5,7 ,Zhongwei Cao1,8,*
1 Key Laboratory of Birth Defects of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu 610041, China
2 Department of Thoracic Surgery, National Frontier Center of Disease Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China
3 Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
4 Fibrosis Research Center, Division of Pulmonary and Critical Care Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5 Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10065, USA
6 These authors contributed equally
7 Senior author
8 Lead Contact
10.1016/j.cmet.2020.11.019
With increasing age comes the reduced ability of organs to regenerate and an increase in fibrosis. In this issue, Chen et al. (pp. 395–410) uncover how age reprograms the crosstalk between vascular and hematopoietic cells to impede regeneration in lung, liver, and kidney, and they show that targeting altered vascular cells induces regeneration without scarring. In this image, locusts represent aging and their biting leads to the destruction of the tree trunk (blood vessel/vascular system). Removing the locusts from the tree gives rise to new green leaves representing regeneration.
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