Molecular Cell
20 October 2022
Targeted protein degradation reveals RNA Pol II heterogeneity and functional diversity
Yuanjun Li1,4 ,Jie Huang1,4 ,Junyi Zhu1 ,Lijun Bao1 ,Hui Wang1 ,Yongpeng Jiang1 ,Kai Tian1 ,Rui Wang1 ,Haonan Zheng1 ,WenJia Duan1 ,Weifeng Lai1 ,Xiao Yi2,3 ,Yi Zhu2,3 ,Tiannan Guo2,3 , Xiong Ji1,*
1 Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
2 Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China
3 Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China
4 These authors contributed equally
10.1016/j.molcel.2022.08.023
The cover shows a Chinese paper-cut. It is composed of the Twelve Zodiac Animals occupying the relative positions of 12 Pol II subunits in the holoenzyme, which constitute the oldest and most auspicious character, “Fu,” in China, representing the pursuit of happiness.
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