Molecular Cell
18 August 2022
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B
Di Chen1,4 ,Mohan Lyu1,4 ,Xiaoxia Kou1 ,Jing Li1 ,Zhixuan Yang1 ,Lulu Gao2 ,Yue Li1 ,Liu-min Fan1 ,Hui Shi2 ,Shangwei Zhong1,3,5,*
1 State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China
2 College of Life Sciences, Capital Normal University, Beijing 100048, China
3 Peking University Institute of Advanced Agricultural Sciences, Weifang 261325, China
4 These authors contributed equally
5 Lead contact
10.1016/j.molcel.2022.05.026
Light and temperature in plants are perceived by a common receptor, phytochrome B (phyB). How phyB distinguishes these signals remains elusive. Here, we report that phyB spontaneously undergoes phase separation to assemble liquid-like droplets. This capacity is driven by its C terminus through self-association, whereas the intrinsically disordered N-terminal extension (NTE) functions as a biophysical modulator of phase separation.
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