Molecular Cell
16 January 2020
Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues
Jun'e Liu1,10, Kai Li1,2,3,10, Jiabin Cai5,6,7,10, Mingchang Zhang8,10, Xiaoting Zhang1, Xushen Xiong1,2,3, Haowei Meng1, Xizhan Xu9, Zhibin Huang8, Jinying Peng1, Jia Fan5,6,7,*, Chengqi Yi1,3,4,11,*
1 State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China
2 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
3 Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
4 Department of Chemical Biology and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
5 Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
6 Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai 200032, China
7 Human Phenome Institute, Fudan University, Shanghai 200032, China
8 Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
9 University of Chinese Academy of Sciences, Beijing 100049, China
10 These authors contributed equally.
11 Lead Contact.
10.1016/j.molcel.2019.09.032
In this issue of Molecular Cell, Liu et al. (pp. 426–440) report the landscape of m6A and m6Am across human and mouse tissues and demonstrate strong tissue specificity for the methylome of brain tissues. The cover shows a metaphorical representation of the m6A and m6Am methylome based on a poem by the Tang dynasty poet Bai Juyi. Due to the different environments (temperature, altitude, etc.), the flowering time of the peach varies alongside the mountain. While the flowers have faded at the foot of the mountain, the peach trees on the mountainside are in full bloom. This peach blossom scenery represents the tissue-specific m6A and m6Am modifications, which are important epitranscriptomic marks in gene expression regulation.
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