Cell Chemical Biology
21 November 2024
Discovery of antibacterial diketones against gram-positive bacteria
Qian Li1,5, Hanzhong Feng2,5, Qiong Tian3, Yun Xiang2, Xiaolei Wang3, Yong-Xing He2,4, Kui Zhu1,6
1 National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
2 Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China
3 State Key Laboratory of Applied Organic Chemistry, Department of Chemistry and School of Pharmacy, Lanzhou University, Lanzhou 730000, China
4 State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China
5 These authors contributed equally
6 Lead contact
10.1016/j.chembiol.2024.06.017
Bacterial respiration is the primary pathway to produce energy, coupling with the electron transport chain (ETC) to transfer electrons. Targeting the ETC leads to energy depletion and bacterial death. In this cover by Li et al., bacteria are depicted as the glowing light bulbs equipped with electrical circuits. Antibacterial compounds block electron transfer leading to bacterial death, which is like interruption of circuits causing the lights to turn off. Hence, targeting the ETC is an attractive strategy to discover antibiotics.
Anhui Province Academy of Science and Technology, No. 128,Wanshui Road, Hi-Tech Zone, Hefei City, Anhui Province, China
+86 17354022649
service@sondii.com
IPv6 network supported
Our hours
Beijing time: 9:00-18:00
